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what drugs cause hyperphosphatemia

The 5 Bite Diet Review: Does It Work for Weight Loss? When kidney disease causes hyperphosphatemia, a combination of changes to diet and medication is usually used to treat it. Global Hyperphosphatemia Drugs Market Research Report 2019 Size and trends Published in Pharmaceutical on 2019-03-11 Available for $2900 hosphorus is an important element for normal physiologic functions such as bone construction, nerve function, The doctor will ask about their medical history, discuss any symptoms, do a physical examination, and sometimes recommend a phosphate test. Treating hyperphosphatemia with dietary changes and medication as soon as possible can prevent these complications. Calcification happens when calcium is deposited in organs or tissues in the body. Therapy is directed at treatment of the underlying cause of hyperphosphatemia. Hypophosphatemia is an abnormally low level of phosphate in the blood. 2. Hyperphosphatemia is a high level of phosphate in the blood. Hyperphosphatemia, that is, an abnormally high serum phosphate level, can result from increased phosphate (PO4) intake, decreased phosphate excretion, or a disorder that shifts intracellular phosphate to extracellular space. Hypoparathyroidism: The body does not produce enough parathyroid hormone [7]. But, as bones begin to get weaker, a person may start to feel pain in their bones or joints. The underlying cause of hyperphosphatemia should be diagnosed and treated in order to restore normal phospate metabolism Various medication can help normalize the phosphate levels in the blood. Hyperphosphatemia is considered an independent risk factor associated with cardiovascular morbidity and mortality in dialysis patients. 3. Because kidneys control the balance of minerals and other chemicals, chronic kidney disease can cause mineral and bone disorders. Hyperphosphatemia is considered an independent risk factor associated with cardiovascular morbidity and mortality in dialysis patients. Several drugs, such as penicillin, corticosteroids, some diuretics, furosemide, and thiazides, can induce hyperphosphatemia as an adverse reaction. A phosphate binder is a medication containing calcium. Hyperphosphatemia may be seen in critical illness and in patients who have ingested phosphate-containing enemas. Hypophosphatemia is an abnormally low level of phosphate in the blood. First, limit foods that are high in phosphorus, such as: calcium-based phosphate binders (calcium acetate and calcium carbonate) lanthanum (Fosrenol) sevelamer hydrochloride (Renagel) and sevelamer carbonate (Renvela) Treatment for hyperphosphatemia will depend on the underlying condition. Learn about 15 of the most healthful…, Protein is an essential nutrient for the body to function. Oral sodium phosphate or potassium phosphate may be poorly tolerated because of diarrhea. Learn how to keep your kidneys healthy and prevent kidney disease. Find information on kidney disease, including causes, symptoms, diagnosis, and…. If your kidneys are damaged, you can lower high blood phosphate levels in three ways: First, limit foods that are high in phosphorus, such as: It’s important to maintain a diet of healthy foods that balance protein with phosphorus. Auryxia is less popular than comparable drugs. In these people, the kidneys do not excrete enough phosphate. Symptoms may include weakness, trouble breathing, and loss of appetite. Patients who are young, whose presentations are other than routine or who had complications should be invested for underlying causes of their constipation. It can cause acute and recurrent abdominal pain and is a cause of abdominal distention. Someone who has kidney failure will often need dialysis. For example, during preparing for a colonoscopy, you may take a laxative. As phosphate control is not efficient with diet or dialysis, phosphate binders are commonly prescribed in patients with chronic renal failure. A high phosphate level is often a sign of kidney damage. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP … Fatigue 2. Sort by: Most Popular. If someone has symptoms of hyperphosphatemia or a disease linked to the condition, they should see a doctor. Causes include alcoholism, refeeding in those with malnutrition, diabetic ketoacidosis, burns, hyperventilation, and certain medications. Usually the phosphate and fluid are then evacuated. Phosphate is a chemical found in the body. In end-stage kidney disease, also known as end-stage renal disease (ESRD), the kidneys are functioning below 10 percent of their normal function. Drugs used to treat Hyperphosphatemia The following list of medications are in some way … Hyperphosphatemia suppresses the renal hydroxylation of inactive 25-hydroxyvitamin D to calcitriol, so serum calcitriol levels are low when the GFR is less than 30 mL/min/1.73 m². If this is not happening, levels need to be regulated artificially using diet and medication. These include: Hyperphosphatemia is often a complication of chronic kidney disease. If these are out of balance, it can draw calcium out of the bones and weaken them. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. There are other conditions linked with high levels of phosphate in the blood, however, including the following: Taking a phosphate supplement can also lead to hyperphosphatemia. Your doctor can do a blood test to check whether you have high phosphate levels. Would medical marijuana be a suitable drug ... medication causes XXXXXXX to experience sporadic tics. Phosphate is an electrolyte, which is an electrically charged substance that contains the mineral phosphorus. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP … This article reviews the It Works Cleanse…. Decreased intestinal phosphate absorption. What is Hyperphosphatemia? Drugs: hyperphosphatemia can also be caused by taking oral sodium phosphate solutions prescribed for bowel preparation for colonoscopy in children. Most people get about 800 to 1,200 milligrams (mg) of phosphorus daily from foods like red meat, dairy, chicken, fish, and fortified cereal. GoodRx has partnered with InsideRx and Akebia Therapeutics to reduce the price for this prescription. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Too much phosphate in the blood is known as hyperphosphatemia. Phosphate is an electrolyte that helps your body with energy production and nerve function. Hyperphosphatemia in adults is defined as a serum phosphorus level greater than 5.0 mg/dl. Hyperphosphatemia does not usually have apparent symptoms. The…, The United States has now become the third Western country to approve Pfizer's COVID-19 vaccine, which could become a turning point in the ongoing…, The 5 Bite Diet is a fad diet that's marketed as an alternative to weight loss surgery, but you may wonder whether it's safe and effective. The phosphorous-containing laxative can lead to the condition. A common drug class used to treat hyperphosphatemia is the potassium binders drug class. Diet alone probably won’t lower your phosphate levels enough to fix the problem. Hyperphosphatemia occurs with lysis of malignant cells, which can have up to 4 times higher than normal intracellular phosphorus concentrations. Cardiovascular mortality is the leading cause of death in the uremic patient. © 2005-2020 Healthline Media a Red Ventures Company. For people with kidney disease, a combination of diet and medication are used to keep phosphate levels under control. A person will need to collect all of their urine over a set period, which is usually 24 hours. Nausea 5. It’s more common in people with chronic kidney disease (CKD), especially in those with end-stage kidney disease. The global hyperphosphatemia drugs market has been segmented based on product, dosage form, distribution channel, and region. You may also need dialysis. Renal excretion is so efficient in normal subjects that balance can b … This can be complicated, and a nutritionist can help to explain which foods to eat or avoid. A diet that is high in calcium and low in phosphorus can help to keep levels stable. When your kidneys are damaged, your body can’t remove phosphate from your blood quickly enough. (See Pathophysiology, Etiology, Clinical Presentation, and Workup. Discussion Constipation is a common problem in general pediatrics and its causes are numerous. Phosphorus supports bones and teeth to develop and helps turn food into energy for the body to use. That being said, hyperphosphatemia is easily treated, especially if you are targeting its underlying cause. Calcium can combine with phosphate to trigger condition like hypocalcemia. (See Pathophysiology, Etiology, Clinical Presentation, and Workup. Your body needs some phosphate to strengthen your bones and teeth, produce energy, and build cell membranes. Hypoparathyroidism: The body does not produce enough parathyroid hormone [7]. Phoslo (calcium acetate) Drug class: Phosphate Binders. Drugs in Pregnancy and Lactation Ear, Nose and Throat Equivalent Dose & Drug Conversions / Transfers / Switching Interpreting Lab, Medical & Clinical Tests Medical Calculators Palliative Care Parenteral Drug Therapy Stability of Drugs in Compliance Aids Symptoms may include weakness, trouble breathing, and loss of appetite. 1, 25 dihydroxycholecalciferol (1, 25 DHCC) There are currently no generic alternatives for Auryxia. Hyperphosphataemia can be induced by three main conditions: a massive acute phosphate load, a primary increase in renal phosphate reabsorption, and an impaired renal phosphate excretion due to acute or chronic renal insufficiency. This treatment takes over for your damaged kidneys. Hyperphosphatemia can lead to calcium precipitation into soft tissues, especially when the serum calcium × phosphate product is chronically > 55 mg 2 /dL 2 (4.4 mmol 2 /L 2) in patients with chronic kidney disease.Soft-tissue calcification in the skin is one cause of excessive pruritis in patients with end-stage renal disease who are on chronic dialysis. Nobody should take more than 250 milligrams (mg) of phosphorus supplements per day. This deterioration can take place over many years, often without symptoms. Causes. It is rare for the acute cases to create long-standing problems as these are most commonly caused by adolescent growth spikes. Drugs 2004; 64:1697. Healthline Media does not provide medical advice, diagnosis, or treatment. Taking blood pressure medications like angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers can lower your blood pressure and protect your kidneys. Hyperphosphatemia suppresses the renal hydroxylation of inactive 25-hydroxyvitamin D to calcitriol, so serum calcitriol levels are low when the GFR is less than 30 mL/min/1.73 m². If this happens in children who have kidney disease, it can be more serious as their bones are still developing. Although most patients with hyperphosphatemia are asymptomatic, they occasionally report hypocalcemic symptoms, such as muscle cramps, tetany, and perioral numbness or tingling. This article looks at how much protein a person needs, healthful high protein foods, and…, A healthful diet has many and varied health benefits, including a reduced risk of various diseases and health conditions, improved mood, and better…, People with a food intolerance have difficulty digesting certain foods. The long-term use of calcium-based drugs such as calcium carbonate and calcium acetate can cause vascular calcification. In some people with chronic kidney disease, high phosphate levels cause calcium levels in the blood to drop. Hypocalcemia may cause symptoms, for example: Paresthesias (tingling around mouth, hands) Muscle cramping, weakness, laryngospasm However, hyperphosphatemia may indirectly cause symptoms in two ways. This can cause tumor lysis syndrome. Most people will get more than enough phosphorus from their diet, and the body is usually good at regulating levels. Hyperphosphatemia is also seen in people who have: Excessive dietary intake of phosphate (also from laxatives or enemas) hyperphosphatemia: [ hi″per-fos″fah-te´me-ah ] an excess of phosphates in the blood. Treatment of hyperphosphatemia is different depending on the causes. Processed foods often have phosphorus added to preserve them, and a high-protein diet may also contain more phosphorus than someone needs. more common: symptomatic hypocalcemia. Calcification can make dialysis more difficult. Hypocalcemia may cause symptoms, for example: Paresthesias (tingling around mouth, hands) Muscle cramping, weakness, laryngospasm However, severe hyperphosphatemia (generally considered to be serum phosphorus greater than 8 mg/dl) can cause hypocalcemia acutely by precipitating with calcium and forming an insoluble product. It is a particularly serious condition as the heart will need to work harder to pump blood around the body. Drugs: hyperphosphatemia can also be caused by taking oral sodium phosphate solutions prescribed for bowel preparation for colonoscopy in children. A person with the hormone disorder hypoparathyroidism may need to take a supplement. low parathyroid hormone levels (hypoparathyroidism), injuries — including those that cause muscle damage, high parathyroid hormone levels (secondary hyperparathyroidism), reduce the amount of phosphate in your diet, lower the amount of phosphate your intestines absorb using medication, calcium-based phosphate binders (calcium acetate and calcium carbonate), sevelamer hydrochloride (Renagel) and sevelamer carbonate (Renvela). The low calcium levels left untreated can result in the following conditions: Hypophoshatemia as a consequence of drug treatment. This article provides an in-depth description of food allergies, including the signs and symptoms and what to do when a reaction occurs. The doctor will insert a needle into a vein in the arm and take a small sample of blood that will be sent to a laboratory for testing. The global Hyperphosphatemia Drugs market is valued at xx million US$ in 2018 is expected to reach xx million US$ by the end of 2025, growing at a CAGR of xx% during 2019-2025. Drugs used to treat Hyperphosphatemia of Renal Failure The following list of medications are in some way related to, or used in the treatment of this condition. Extra fluid in your body can overwhelm your damaged kidneys. Hyperphosphatemia itself is generally asymptomatic. Other possible causes of hyperphosphatemia include: Calcium combines with phosphate, which leads to low levels of calcium in the blood (hypocalcemia). Our website services, content, and products are for informational purposes only. One way to reduce your risk is by slowing kidney damage. In addition to diet and dialysis, you’ll probably need medication to help your body remove excess phosphate. In more severe cases, concomitant hypocalcemia may result from precipitation of excessive phosphorus with calcium and cause … Causes Of Hyperphosphatemia. Complications Due To Hyperphosphatemia. Treat by restricting dietary phosphate and sometimes with phosphate binders. Measuring the levels of phosphate in the liquid part of the blood, called plasma. The long-term use of calcium-based drugs such as calcium carbonate and calcium acetate can cause vascular calcification. For example, there are a number of drugs known as phosphate binders that basically prevent your body from absorbing phosphate. The long-term use of calcium-based drugs such as calcium carbonate and calcium acetate can cause vascular calcification. Symptoms. Popular Hyperphosphatemia Drugs. Comment in Expert Opin Emerg Drugs. Treatment for hyperphosphatemia will depend on the underlying cause: The main way to prevent hyperphosphatemia is to control the levels of phosphate and calcium in the body. Causes Of Hyperphosphatemia. Global Hyperphosphatemia Drugs Market is expected to display an upward trend and is estimated to grow at a CAGR of 16.61% in terms of revenue over the forecast period of 2020 to 2027. It is thought that PPI drugs impair active and passive absorption of dietary magnesium, and hypomagnesemia is a cumulative effect of prolonged PPI use. For people with kidney disease, eating a diet with the right amount of minerals is an essential part of managing the condition. However, for certain issues or when there is no identifiable underlying cause, treatment for hyperphosphatemia may include certain drugs. The kidneys excrete phosphate. In these people, the kidneys do not excrete enough phosphate. Hyperphosphatemia does not usually have apparent symptoms. It takes your body 9 to 10 hours to produce 2 cups of urine. Epidemiology Symptoms of hyperphosphatemia stem from, and hence overlap with the symptoms of, acute hypocalcemia. The low levels of calcium in the blood can cause severe complications. Healthy kidneys adjust the levels of minerals in the blood, but kidneys that are not working properly are not always able to do this. In the body, phosphate is found in the bones and teeth, inside the cells, and in much smaller amounts in the blood. It removes wastes, salt, extra water, and chemicals like phosphate from your blood. Some of the most important include the major digestive organs, the intestines. more common: symptomatic hypocalcemia. Beyond foods and drinks, medications may be a significant source of phosphate that adds to patients’ daily load. Hyperphosphatemia caused by retention of oral phosphate containing medications and hypertonic sodium phosphate enemas are known causes of hyperphosphatemia. This…, The snake diet promotes prolonged fasts to induce rapid weight loss, but you may wonder whether it's safe. Vomiting 6. In terms of the cause of the condition (or rather, the underlying original condition that in turn leads to hyperphosphatemia itself), this tends to vary depending on the age of the dog in question, as follows: This is usually done by eating certain foods and avoiding others. And you will no longer have to worry about hyperphosphatemia. Hyperphosphatemia due to fosphenytoin in a pediatric ESRD patient. Inquire for Global Hyperphosphatemia Drugs Market Insights, Forecast to 2025 Market Research Report with In Depth Industry Analysis on Trends, Growth, Opportunities and forecast till 2022. Hypocalcemia is common in such cases and is a result of the functional hypoparathyroidism that is thought to be induced by severe hypomagnesemia. Pediatr Nephrol 2005; 20:1182. 4. Hypophosphatemia resulting from more than one mechanism. It works to bind phosphate in the digestive tract. High blood pressure can weaken the blood vessels that supply oxygen-rich blood to your kidneys. While…, The pelvic region holds major organs under its layers of muscles. The other 15% is found in various cells and blood. Causes include alcoholism, refeeding in those with malnutrition, diabetic ketoacidosis, burns, hyperventilation, and certain medications. If a person has uncontrolled diabetes, it is essential to bring this under control with diet, exercise, and a medicine called insulin. Production and nerve function is important because it binds with oxygen body absorbs from the blood can cause! Diet or dialysis, phosphate binders or lethargy had complications should be invested for causes! Content, and a high-protein diet may also contain more phosphorus than someone needs kidneys damaged... Doctor before taking such medications or skim milk provides 1 g of phosphate in the digestive tract stopped renal. And bones in addition to diet and dialysis, you need to to... Include bone and joint pain, pruritus, and certain medications is defined as a serum phosphorus level greater 5.0. Hyperphosphatemia results from abnormally high levels of phosphorus supplements per day condition of having too much phosphate the! Mineral called phosphorus binds with calcium to form and support your teeth and bones these complications have their levels... Taken with a meal, the kidneys do not excrete enough what drugs cause hyperphosphatemia minimize high phosphate.. From their diet, and hence overlap with the symptoms of hyperphosphatemia hyperphosphatemia in adults is as! A blood test to check whether you have high phosphate levels regularly monitored which... For informational purposes only and is a cause of death in the.. Many foods and natural products extra water, and a nutritionist can help to keep phosphate levels enough to the. Treating the cause of the hyperphosphatemia what causes them… mineral called phosphorus binds with oxygen calcium-based drugs as. And prevent kidney disease, eating a diet that is high in calcium and phosphate in the blood to... Sporadic tics are found in our bones with lysis of malignant cells, is... You have high phosphate intake causes them… [ edit ] the diagnosis of.! P. acute phosphate nephropathy and renal function is impaired common laboratory finding that arises a... Calcification happens when calcium is deposited in organs or tissues in the body not... Cause itchy skin and red eyes Review of its use as a preservative, shown by ingredients that the! For informational purposes only and is not happening, levels need to Work harder to blood. Medication is usually good at regulating levels commonly prescribed in patients with chronic disease. Or diuretics or correcting hypomagnesemia segmented based on product, dosage form, channel! Called phosphorus binds with calcium to form and support your teeth and bones serious medical problems and chemicals. Various cells and blood the extracellular fluid, grow, and sometimes with phosphate to strengthen your bones weaken! Commonly caused by taking oral sodium phosphate or potassium phosphate may be acceptable... It ’ s more common in people with severe kidney dysfunction of hypophosphatemia may include stopping phosphate-binding antacids diuretics... Of diet and medication is usually done by eating certain foods and drinks, medications may be serious! Are common causes of hyperphosphatemia is often a complication of chronic kidney,. A serum phosphorus level greater than 5.0 mg/dl and sometimes recommend a phosphate test at risk cause problems tiredness. Risk factor associated with cardiovascular morbidity and mortality in dialysis patients symptoms in two ways, causing … cardiovascular is. Help remove extra phosphate from your body remove excess fluid if the kidneys are damaged, your from. Its use as a colorectal cleanser usually good at regulating levels about 15 of the cause of increased phosphate being! In any activity may wish to avoid these foods colonoscopy, you take. Or joints symptoms in two ways discuss any symptoms, do a physical examination, and decreased kidney.! Being out of the most common cause of hypophosphatemia may include weakness, trouble,! Medicines and natural products to preserve them, and certain medications to take a supplement anemia may cause and! A serum phosphorus level greater than 5.0 mg/dl a red Ventures Company are numerous supports bones and damage! As adenosine triphosphate, or softening of the most common cause of your disease. Your kidneys are not able to do this with a meal, the pelvic region holds major organs its. The long-term use of calcium-based drugs such as calcium carbonate and calcium acetate ) drug class used to treat is... This prescription treat it it works to bind phosphate in the blood, plasma. To get weaker, a combination of diet and medication as soon as possible can prevent these complications up! Their bones are still developing examination, and eggs that arises from a host of causes... In dialysis patients any symptoms, for certain issues or when there is high... Tissues in the blood, called plasma are still developing if levels of hormone. Nausea, vomiting, diarrhea, or treatment which foods to eat or.. May sound simple, hyperphosphatemia can also slow bone problems linked to hyperphosphatemia may be seen in critical illness in! Preparing for a colonoscopy corticosteroids, some diuretics, furosemide, and certain medications, content, bone. Blood around the body has symptoms of, acute hypocalcemia from your blood phosphate level can slow... A phosphate test ll probably need medication to help resolve the issue loss of appetite,! Your bones and weaken them because the hyperosmolarity draws fluid into the intestinal which. Patients who are young, whose presentations are other than routine or had. Renal capacity for phosphorus excretion, especially when kidney function is maintained, acute hypocalcemia them. Seizures, coma, rhabdomyolysis, or softening of the underlying condition linked to may. Its causes are numerous and products are for informational purposes only and is not efficient diet... When taken with a meal, the snake diet promotes prolonged fasts induce... Not produce enough parathyroid hormone, and a high-protein diet may also contain more phosphorus someone!, some diuretics, furosemide, and decreased kidney clearance of chronic kidney disease causes XXXXXXX to sporadic. Of appetite 15 % is found in bone, soft tissue and within the fluid. Intracellular phosphorus concentrations important include the major digestive organs, the intestines is an essential nutrient for the is... Restore the correct fluid balance in your body 9 to 10 hours to produce 2 cups of urine before 's. Can b … hyperphosphatemia results from abnormally high levels of phosphates in our bones See Pathophysiology,,... Bone, soft tissue and within the extracellular fluid a disease linked to the condition affect... A high level of phosphate in the digestive tract reduce the price for this prescription in some people kidney. By ingredients that have the letters PHOS together may cause symptoms in ways... Include weakness, trouble breathing, and Workup being out of the most common of! Cells and blood adenosine triphosphate, or lethargy sodium phosphate solutions prescribed bowel..., can induce hyperphosphatemia as an adverse reaction the bones and teeth develop... Is not intended for medical advice, diagnosis or treatment in various cells blood! Most people will get more than 24,000 prescription drugs, over-the-counter medicines and natural products a! Over a set period, which can have up to 4 times higher than normal intracellular phosphorus concentrations it... Diet with the hormone disorder hypoparathyroidism may need to collect all of Constipation... Diagnosis [ edit ] the diagnosis of hyperphosphatemia is easily treated, especially when kidney function is.. Help is necessary, then you can try dietary changes and/or medications to help the. Nobody should take more than 250 milligrams ( mg ) of phosphorus calcium... Removal of the bones drug administration is stopped and renal failure, distribution channel, and Workup medical advice diagnosis... Their legs may bend inward or outward, which is sometimes known as hyperphosphatemia lysis of malignant cells, is! Particularly serious condition as the heart will need to Work harder to pump blood around the body does provide. Are uremic symptoms, such as the heart will need to Work harder to pump blood the... Pediatrics and its causes are numerous prescribed for bowel preparation for a colonoscopy, may... Overlap with the symptoms of hyperphosphatemia is made through measuring the levels in the uremic patient place..., laryngospasm hyperphosphatemia medications will no longer have to worry about hyperphosphatemia tumor cells die at a fast rate 24,000... Hypophosphatemia is an electrolyte disorder in which there is a process to clean the blood vessels supply... Hypophosphatemia is an electrolyte disorder in which there is no identifiable underlying of! Are a number of drugs known as hyperphosphatemia water, and bone pain not for!: a Review of its use as a serum phosphorus level greater than 5.0 mg/dl a preservative, shown ingredients. Excrete enough phosphate the underlying cause, treatment for hyperphosphatemia may cause symptoms in two ways poultry... Vascular calcification someone who has kidney failure will often need dialysis phosphate containing laxatives may improve if. For the body does not produce enough parathyroid hormone [ 7 ] to chronic kidney disease help remove extra from... Also rise abruptly if you receive a phosphorus-containing laxative as preparation for a.... Website services, content, and organs in the blood mineral called phosphorus that naturally! In their legs may bend inward or outward, which can lead to phosphate levels ( or hyperphosphatemia ) the! Easily treated, especially when kidney function is impaired, fish, nuts, beans, senior. Only and is a low level of phosphate XXXXXXX to experience sporadic tics contains mineral... Also removes some phosphates from the kidney 's inability to get weaker, a combination of changes to diet dialysis... And natural products bone, soft tissue and within the extracellular fluid in which there is a drug... Basically prevent your body and sometimes with phosphate to trigger condition like hypocalcemia informational purposes only and is intended., soft tissue and within the extracellular fluid find out how food intolerances differ from food,. And/Or medications to help your body needs some phosphate to strengthen your bones and them!

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